Loneliness Feeling sad and unhappy about being socially isolated. Common causes of this symptom Loneliness can be normal, and is only an indicator of underlying disease when feelings become excessive, all-consuming and interfere with daily living. Self-treatment Volunteering, attending community or religious events or taking a class may help form new friendships and reduce loneliness. Going for a meal, coffee or a walk with family or friends may also help. #loneliness